microcrystalline cellulose msds fmc microcrystalline cellulose msds fmc

MCC helps in the formation of spheres because of its . More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. Microcrystalline cellulose is a commonly used excipient in the . Battista, O. Avicel RC-591 & CL-611 - Description. endobj 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 6 0 R/Group<>/Tabs/S>> % Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. lH5JWy}DgKRR"Fs IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Material Name: Estradiol Tablets Trade Name: RONFASE . Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. 51395-75-6 Avicel RC 591. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? << 2021 Annual Report. Microcrystalline Cellulose E460 MSDS 1. 3 0 obj The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. By producing Avicel . )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. X\o^ The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. };khd5x=fr FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. Microcrystalline Cellulose NF. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. The typical mean particle size is 20200 m. CAS 9004-34-6, pH 5 - 7.5. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication endobj The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . Production of Pharmaceutical Grade Microcrystalline Cellulose. More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. Revision No. They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose. HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. However, consumption of large quantities of the material may have a laxative effect. <> Cellulose microcrystalline. ( Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization. MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. No. Microcrystalline Cellulose Side Effects. /Resources 2 0 R xv}O2' H~KEe9>G/,:9\i MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. Microcrystalline cellulose -The oldest polymer finds new industrial uses,. Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. Your file is uploaded and ready to be published. Explore how you can develop your career and bring your creative ideas to life at IFF. 4. PharmaCentral 2021 . cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q c Dh)#t'kTfIZT1-_y"+wXj,qo!~ozc}ZemZ``$'vj{, Ga;]2iY*DIh~F3Z!.pkL:bHHBTbIcw9.Xo$4,?On4s=R,KLz /M|#PF(j%j oF2[5 ,rx)bd1$LM4Dc-d\@W D?A?L/7>s]-};Z if^+e3}AeQ# U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. Performing this action will revert the following features to their default settings: Hooray! Doses up to 30 g per day appear to be . It is . Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> Well-recognized product that can do it all. As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. CAS #: 9004-34-6 1.6. Molecular weight: Not Applicable 1.5. All Rights Reserved. X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? 0.25 - 0.37. Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . Avicel PH-200 microcrystalline cellulose NF, Ph. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . MATERIAL SAFETY DATA SHEET. GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. Alginates also function as actives in some anti-reflux products. However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? These, in turn, are assembled into fibrils in the cell wall. Product Name: Microcrystalline Cellulose E460 1.2. IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. Micro Crystalline Cellulose. This extends the funcionality of microcrystalline cellulose to meet specific viscosity, gelling, suspension and stabilizing properties ChemPoint is an approved supplier of LATTICE MCC in industrial applications, providing dedicated marketing, sales, order fulfillment, and technical support for customers in the EMEA region, Protect and improve AI potency, entrap oil droplets and improve stability, physical barrier that helps suspend particles and breaks down under shear and reforms quickly under rest. Page 1 of 8. SUBSTANCE IDENTIFICATION 1.1. Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . Regulatory Information We are artists at heart and creators by nature. < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. 1 0 obj MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. q86@on$^X_HuH;3` Microcrystalline Cellulose / Avicel PH-102. : 1. Created Date: 2/10/2020 8:51:41 PM . ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. PDF (28.38 mb) 2022 Corporate Fact Sheet. Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. MSDS Ref. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . Learn about FMC's industry leading goal of net-zero emissions by 2035. Trademarks: Avicel PH-102. Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. Have an order or account question, find answers in our Online Support articles. Microcrystalline Cellulose / Avicel PH-102. Microcrystalline Cellulose (MCC) MSDS 1. Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. Chemical Formula: (C6H10O5)n 1.4. Remove Browse Avicel PH-101 and related products at MilliporeSigma. endobj In 1964 FMC, Corporation . 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W >> Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. Safety Data Sheet for Cellulose microcrystalline 102331. INCI. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. Buy Chemicals. Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. Instead, they obtained a stable colloidal suspension. It is also used in plaque assays for counting. Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. Van Veen, G.K. Bolhuis, Y.S. Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. %PDF-1.5 << It . SDS. . Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . w !1AQaq"2B #3Rbr % The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. Combines good flow and high compactibility. ( The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. Hi, let us know if you have any questions as you visit our website. The most. SUBSTANCE IDENTIFICATION 1.1. pH 6.0 to 8.0 . Some substance identifiers may have been claimed confidential, or may . The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. Microcrystalline Cellulose (MCC) Manufacturing Industry. !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. Apply today! In large quantities it provides dietary bulk and may lead to a laxative effect. Home. Learn about FMC's differentiated biologically-based crop solutions. Are you sure you want to delete your template? endobj Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. Avicel PC 611 (FMC Biopolymer) Supplied by. Origin(s): Plant/Botanical. Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. Quantity: 1 700 kgs. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. Revision No. Molecular Weight null. Gloves, eye protection and a dust mask should be used. Chemical Formula: (C6H10O5)n 1.4. ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO! Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. The cellulose molecule is formed through repeated condensation of cellobiose units. The 'Substance identity' section is calculated from substance identification information from all ECHA databases. *r_ *?~4$ &0Y# Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. Avicel Microcrystalline cellulose occurs as a white, odourless, tasteless, fibrous powder composed of porous particles. >> All Rights Reserved. endobj The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. 4 0 obj The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. q9;v80q>jZ iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e ^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w 'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. High performance lubricant that brings more to the tablet. Wu, K. Zuurman, H.W. Report Category. Heavy metals, % NMT 0.001 : CL-611NF Date Approved: 01/13/2010. stream Material safety data sheet - FMC Corporation. A family of polysaccharide products that allow distinctive drug delivery solutions. No. Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. Cellulose microcrystalline for column chromatography. %PDF-1.3 JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; It is also inert and biocompatible. /Contents 4 0 R The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements. : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. 8 0 obj {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no All rights reserved. Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. Thus, Avicel contributes no or very few calories to the food system. Test Data Available. The short-term limit for total inhalable dust is 20 mg/m3. << Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. stream Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . It is, however, a good source of fibre. They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. Meet our leadership team. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. It is hygroscopic and insoluble in water. : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Are you looking for information about products and services by region? There may be more fiber in your food than you realized. "l%I-*j|-)@ EtG[TQd%8,.fg4QqH'-dV ?3Z#GK# dGnF7x*3yY\VUwPhmyYT@f67Zcsmdi!%94K@:L# vJeU-kzRT-(YX/fKC CoA. : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. /Type/Page FMC Corporation. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. MSDS Ref. POLYOX resins are nonionic polyethylene oxide solubility polymers. Avicel Microcrystalline Cellulose: Chemical Identifiers. . With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. . MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. Request media, explore upcoming events and read our latest updates. Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . YUMPU automatically turns print PDFs into web optimized ePapers that Google loves. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. 102331. Avicel co-processed grades are co-spray dried blends of Avicel microcrystalline cellulose with synergistic pharmaceutical excipients to yield functional benefits beyond simple physical blends. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). Catalog Number 102331. Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. 1. BIOACCUMULATIVE POTENTIAL The figure below illustrates the structural organisation of cellulose within plants. Terms and Conditions Compliance Solutions Industries About 3E News & Events . 2008-2023 ChemPoint. Protect them from sunshine or rain. SDS - Safety Data Sheet. They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. <> Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents. Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. Aquacoat CPD is an aqueous dispersion of cellulose acetate phthalate used for enteric release applications. The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. Have an order or account question? There have always been two different points of view for the liquidity of MCC. The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC aB s!YaxHWtGr"GQ 5S"fMS+_;x@@5 zjrK=;OA:il)b> e ei'wm~oh!=Z@Y:J0#8On`T./iC}^o%7KS"$ rf*Z;JTL-uOHH%%Z,029J_ ( endstream endobj 526 0 obj 465 endobj 527 0 obj << /Filter /FlateDecode /Length 526 0 R >> stream Molecular weight: Not Applicable 1.5. Synonyms: Cellulose, Cellulose powder, Cotton linters. Explore how we work and why we apply science and creativity for a better world to everything we do. Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. No. J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P %PDF-1.4 4 0 obj Watch Now. Avicel Microcrystalline Cellulose Physical Properties. endobj <> We know that our customers need to provide reliable and consistent products to their patients. 1.3. % MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose.